Uncovering a Macrophage Transcriptional Program by Integrating Evidence from Motif Scanning and Expression Dynamics
Figure 3
Early induced gene clusters are enriched for transcription factors.
Each circular data point indicates a cluster. The horizontal axis is the estimated time scale for the differential expression level of the genes within the cluster to reach 25% of the maximum absolute differential expression (the “response time”). The response time was computed under LPS stimulation of wild-type macrophages (see Materials and Methods, Expression Clustering). The horizontal dashed line indicates the average fraction of genes that are known transcription factors, among all annotated genes in the mouse genome (0.053, see Materials and Methods, Selection of Transcription Factors). The slope of the best-fit line to the scatter plot is −3.84 (Pearson's R = −0.74).