A Novel Bayesian DNA Motif Comparison Method for Clustering and Retrieval
Figure 8
Condition dependent behavior of Ste12.
(A) A Venn diagram representing the results of the ChIP-chip experiment [13] for Ste12 under mating (induced by alpha factor) and filamentous growth (induced by butanol). Ste12 alters its targets substantially between these two conditions. (B) Analysis of the percent of sequences bound by Ste12 which contain the different motifs (when searching for motif occurrences at 2% false positive rate). Shown are the different motifs in the targets bound by Ste12 in filamentous growth condition only (yellow), in mating condition only (blue), or in both conditions (green). Each motif is shown as a sequence logo on the left and percent occurrence in each group as bar chart on the right. We can see that under filamentous growth there is enrichment for a motif similar to the previously characterized Ste12 motif (top motif), as well as the known recognition sequence of Tec1 (third from top). Under mating there is an enrichment for a near-perfect tandem repeat of Ste12 known binding site (second from top). A motif similar to the known Mcm1 motif (bottom motif) is found to be enriched under both conditions, especially under filamentous growth.