A Novel Bayesian DNA Motif Comparison Method for Clustering and Retrieval
Figure 6
Overview of the discovered motifs.
Investigation of the properties of discovered motifs. Each motif (column) is compared to other motifs using the BLiC score (rows, top square), to enrichment of putative targets among expressed or silenced genes within a compendium of gene expression at different cellular conditions (second group), to the enrichment of targets within various GO annotations (third groups) and in ChIP-chip location assays (bottom group). The rows and columns were clustered using EdgeCluster [33], an agglomerative clustering procedure that integrates various sources of information into the clustering process. Shown is clustering for partial sets of motifs related to the transcription factors: Fhl1, Sfp1, Rap1, Hsf1, Ste12, Mcm1, Swi4, Swi6, and Mbp1 (the full clustering is presented in Figure S4 and on http://compbio.cs.huji.ac.il/BLiC).