Systematic Analysis of Pleiotropy in C. elegans Early Embryogenesis
Figure 2
A correlation map for pairs of defects involved in C. elegans early embryogenesis.
We calculate the ratio of observed co-occurrence to the expected co-occurrence for every pair-wise combination of defects and plot the ratios into a correlation map. A ratio that is higher than 1 indicates the two defects are more likely to co-occur than expected by chance. Some defects, such as P1/AB nuclear separation—cross-eyed and four-cell stage nuclei—size/shape (pointed to with a black arrow), co-occur at a very high frequency. In this map, the co-occurring defects are grouped together by hierarchical clustering.