Accurate Structural Correlations from Maximum Likelihood Superpositions
Figure 4
ML Superposition and PCA Plot of Homologous Telomere Domains
(A) An ML superposition of the first OB-fold from 1otc (blue), 1s40 (magenta), and 1qzg (cyan).
(B) A PCA plot of the first principal component based on the ML superposition in (A), plotted on the mean structure. Two functionally critical loops, shown in blue, are implicated in telomeric ssDNA substrate recognition. These loops are highly correlated, indicating that their conformations have evolved in concert.