In Silico Detection of Sequence Variations Modifying Transcriptional Regulation
Figure 5
Combination of TFBS Analysis and Phylogenetic Footprinting
Sensitivity of the predictions is plotted versus 1-specificity for phastCons score thresholds of 0, 0.1, 0.2, etc., up to 0.9. The whole range of values is only shown for the red curve; for the other curves, values for phastCons score thresholds 0 and 0.1 are outside the area covered by the plot. The curves correspond to different TFBS score delta thresholds. In the left panel, the relative TFBS score threshold for the best matching allele was 80%, in the right panel the relative TFBS score threshold for the best matching allele was 90%.