In Silico Detection of Sequence Variations Modifying Transcriptional Regulation
Figure 3
Fractions of Regulatory and Background SNPs in Evolutionary Conserved Regions
SNPs were given the mean phastCons scores from multiple alignments of human, chimp, mouse, rat, dog, chicken, fugu, and zebrafish in windows of 21 bp centered at the SNPs. The fractions of SNPs located within conserved regions were calculated for mean phastCons score thresholds between 0.1 and 0.9. For every threshold a Fisher's exact test was performed to test if there was a significantly different frequency of successes in the regulatory versus the background SNP sets; p-values are indicated above each pair of bars.