An Evolutionary-Network Model Reveals Stratified Interactions in the V3 Loop of the HIV-1 Envelope
Figure 4
Structural Model of the V3 Loop
A three-dimensional visualization of the structure of the V3 loop, using structural coordinates from a model comprised of the HIV-1 gp120 core protein complexed to the CD4 receptor and the X5 antibody [28]. The structure is oriented such that the host cell membrane would be positioned at the top of the figure. The cysteine residues forming a disulfide bridge that closes the loop are labeled in green. The amino acid sequence depicted here differs from our consensus sequence at five positions, such that identity would require the following substitutions: Q5N, H12R, R17Q, T21A, and E24D.