Control of Membrane Fusion Mechanism by Lipid Composition: Predictions from Ensemble Molecular Dynamics
Figure 3
Kinetics of Vesicle Fusion Simulated at Different Lipid Compositions
The relative concentrations of fusion intermediates and fused vesicles are plotted for each time point of the simulation for (A) pure POPE, (B) a 1:1 POPC:POPE mixture, and (C) a 2:1 POPC:POPE mixture. Predictions are derived from MSM analysis of all fusion trajectories. Dotted lines represent 90% CIs.