Self-organizing Mechanism for Development of Space-filling Neuronal Dendrites
Figure 3
Distinctive Dendritic Patterns Obtained from the Computer Simulation of the Cell Compartment Model
(A–C) and (D–F) Two distinct patterns obtained by using different parameter values in the activator–suppressor model. Whole images of dendritic trees (A,D), magnified images of the activator (B,E) and those of the suppressor (C,F). Examples of branch-poor arbors and branch-rich arbors were indicated in yellow and blue, respectively, (A) and (D). Density of the activator is relatively high at the terminal of each branch (arrows in “B”). Alternatively, dendrites elongate as new spots are generated (arrows in “E”) and bifurcate as spots undergo fission (arrowheads in “E”). Parameter values were pa = 0.9 and pe = 6.5 (A–C) and pa = 0.5 and pe = 2.6 (D–F). Other parameters were pb = 0.8, d = 30.0, ph = 1.0, Tr = 1.0, Amax = 30.0, R = 0.004, and γ = 625. The grid size is 800 × 800, dx = 0.02, and dt = 1 × 10−6.