Empirical Multiscale Networks of Cellular Regulation
Figure 4
Targets of Module Regulation, Showing Increasing Specificity at Finer Scales
(A) Examples of regulatory targets. Activated (green) or inhibited (red) modules of the regulatory module marked in gray. Influences passing the edge inclusion threshold are shown. Targeted modules tend to be spatially localized in the SOM array, i.e., modules expressed similarly across perturbations tend to receive inputs from the same activators and inhibitors).
(B–E) Target influence SOM arrays (unthresholded) clustered by similarity at n = 12, 20, 42, and 72 (B–E, respectively). For example, the first array in (A) corresponds to module 8 in (E) (second row, second position from the right).
(F) The degree of target specificity (fraction of branch points not on the longest arm of the clustering tree) versus network scale. The sigmoidal shape of this curve is suggestive of a transition around n = 30 from global regulation to higher target specificity.