Empirical Multiscale Networks of Cellular Regulation
Figure 2
Effective Regulatory Influences at Many Scales (Top to Bottom) over a 1.5-h Interval
(A,E,I,M) Regulatory influence networks, with red arrows indicating inhibition and black activation. An influence is included if the magnitude of its mean across all regulatory contexts is more than twice its standard deviation. Predominantly activating modules (green boxes), predominant inhibitors (red boxes), and modules without outputs (white boxes) are adjacent. Numbers in boxes are SOM module numbers.
(B–C,F–G,J–K,N–O) Average magnitudes of outputs (B,F,J,N) and inputs (C,G,K,O) of modules arranged in SOM array order. Stronger inhibition, activation, or neither are indicated by brighter red, green, or gray, respectively.
(D,H,L,P) Complete unthresholded n × n regulatory transition matrices. Rows are sorted by similarity in functional inputs, and columns are sorted by similarity in functional outputs.