Enzyme Localization Can Drastically Affect Signal Amplification in Signal Transduction Pathways
Figure 6
Response Curves at Different Positions in the Cell
Dose–response curves of the push–pull network in which the activating enzyme is localized at one pole of the cell, while the other components diffuse in the cytoplasm, for different positions in the cell (x = 0 corresponds to the black left most curve, while x = 3 μm corresponds to the black right most curve). Profiles of [X*] (A) and profiles of [EdX*] (B); note that the response becomes sharper farther away from the pole. The green curves correspond to the average or integrated response of the non-uniform system, while the red curves correspond to the uniform system. The inset shows the logarithmic gain g ≡ ∂ln[X*] / ∂ln[Ea]T at the respective positions in the cell (x = 0,1,2,3, μm). For the parameter values, see Figure 4.