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Enzyme Localization Can Drastically Affect Signal Amplification in Signal Transduction Pathways

Figure 5

Effect of Diffusion on the Concentration Profiles: Weak versus Strong Activation

Profiles of [X*] (A,D), [EdX*] (B,E), and [Ed] (C,F).

(A–C) Low concentration of activating enzyme, [Ea]T = 0.5[Ed]T.

(D–F) High activating enzyme concentration, [Ea]T = 1.5[Ed]T.

For the other parameter values, see Figure 4.

Figure 5

doi: https://doi.org/10.1371/journal.pcbi.0030195.g005