Enzyme Localization Can Drastically Affect Signal Amplification in Signal Transduction Pathways
Figure 4
Concentration Profiles of a Spatially Non-Uniform Push–Pull Network
The concentration profiles of X* (A) and EdX* (B) in a push–pull network in which the activating enzyme is located at one pole of the cell, while the other components are distributed in the cytoplasm, for three different concentrations of the activating enzyme. For all curves, [S]T = 20 μM, [Ed]T = 0.5 μM, KM,a = KM,d = 0.5 μM, k3 = k6 = 25s−1, and D = 10 μm2 s−1.