Elucidating the Altered Transcriptional Programs in Breast Cancer using Independent Component Analysis
Figure 8
Average association networks shown for ER status (A) and clinical outcome (B). Only edges between phenotypes, pathways, and transcription factors are shown (for the sake of clarity, edges between any two pathways, transcription factors, or phenotypes are not shown). An edge between two nodes was defined if the association between the two nodes was present in at least three out of the four studies, as predicted by the KernelICA algorithm. The diagrams are colour-coded as follows: phenotype (red), pathways (green), and transcription factors/binding motifs (blue).
INFLR, inflammatory response; TM, tyrosine metabolism.