Elucidating the Altered Transcriptional Programs in Breast Cancer using Independent Component Analysis
Figure 7
Inter-Method Comparison of Selected Associations of Pathways and Regulatory Modules with Breast Cancer Phenotypes
The ability of the various methods to capture novel biological associations between pathways/regulatory modules and phenotypes is represented as a binary heatmap across methods and cohorts. (A) Immune response pathway and ER status, (B) EMT-pathway and grade, (C) IRF and ER status, (D) Neurofibromin-1 and clinical outcome. Black denotes a statistically significant association between a pathway/regulatory module and the phenotype in question, white means no evidence of an association.