Elucidating the Altered Transcriptional Programs in Breast Cancer using Independent Component Analysis
Figure 3
Most Consistent and Frequently Mapped Pathways and Regulatory Motifs
(A) For each method, we compare the number of pathways that were consistently mapped to components across the four major breast cancer studies.
(B) Twenty of the most frequently mapped pathways by ICA. The scores give the average number of ICA components in which the pathway was mapped.
(C) For each method, we give the number of motif-regulatory gene sets consistently mapped to components across the four major breast cancer cohorts.
(D) The 20 most frequently mapped transcription factors/regulatory motifs by ICA. The scores give the average number of ICA components in which the regulatory module of the motif was mapped.