Image-Based Modeling Reveals Dynamic Redistribution of DNA Damage into Nuclear Sub-Domains
Figure 5
Spatial Foci Pattern Increasingly Deviates from Prediction Following 1 Gy of 1 GeV/amu Fe Exposure
(A) Plots the correlation between theoretical and experimental distributions of distances between consecutive foci along Fe tracks over the first hour following exposure to radiation. All DNA damage markers used (i.e., γH2AX, ATMp, 53BP1) show the same loss of correlation to randomness over time.
(B) Shows the corresponding foci frequencies, depicting a rapidly decreasing curve indicative of DNA repair.