Global and Local Architecture of the Mammalian microRNA–Transcription Factor Regulatory Network
Figure 6
Analysis of miR Clusters in the Human Genome
(A) Distribution of distances between all neighboring pre-miR genes in the human genome.
(B) Distribution of tissue expression correlations between pairs of miRs: all possible pairs in the data (thin blue line) and pairs of miRs which reside in shared clusters (thick red line). In the inset are shown tissue expression correlations between pairs of miRs in the same genomic clusters versus distances between them.
(C) Distribution of number of conserved TFBS 30 kb upstream of the 5′ most nucleotide in each miR clusters. Conserved TFBSs were taken from UCSC hg17.