Global and Local Architecture of the Mammalian microRNA–Transcription Factor Regulatory Network
Figure 5
Tissue Expression Correlations between miRs and TFs
miR tissue expression in brain, liver, thymus, testes, and placenta were taken from [34]. mRNA tissue expression was taken from [35].
(A) Background distribution of all possible miR–TF pairs for which expression profiles can be derived.
(B,C) Normalized histograms of correlation coefficients; the same distribution as in (A) was made, yet only for significantly co-occurring miR-TF pairs (red), and FFLs (green) in the PicTar (B) and TargetScan (C) networks. The figure shows the proportion of the various correlation coefficients divided by the background distribution depicted in (A).