Efficiency, Selectivity, and Robustness of Nucleocytoplasmic Transport
Figure 3
Transport Efficiency Is Determined by the Interaction Strength
(A) Transport efficiency, as given by the probability to reach the nucleus, is shown as a function of the interaction strength. RanGTP activity in the nucleus is represented by using JranL2/(N2D) = 1.5. The curves correspond to four different values of the entrance rate, J (measured in units of 10−416D/R2); the red line is the low-rate limit of Equation 4. For any entrance rate, the transport efficiency is maximal at a specific value of the interaction strength, which provides a mechanism of selectivity.
(B) Optimal interaction strength of (A) as a function of the incoming rate J (in units of 10−416D/R2), for JranL2/(N2D) = 1.5; parabolic potential shape. See Discussion for the corresponding actual values of the flux through the pore. Black dots are simulation results.