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Sarcomere Lattice Geometry Influences Cooperative Myosin Binding in Muscle

Figure 4

Transient Predictions

Temporal predictions of average relative force (A), fractional thin-filament nodes available to bind with myosin, f_a (B), and fractional cross-bridge binding, f_xb (C) for the multi-filament (black) and two-filament (green) models at pCa levels 4.0, 6.0, and 7.5 (pCa = −log₁₀ [Ca²⁺]). The number of simulations trials averaged to generate each trace (N_runs or 24N_runs) is summarized in Table 3. Our standard mechanical parameters apply to these simulations: k_xb = 5, k_a = 5229, and k_m = 6060 pN nm⁻¹.

doi: https://doi.org/10.1371/journal.pcbi.0030115.g004