The Human Genomic Melting Map
Figure 2
Correlations of Melting Temperature (Tm) with G + C Content
The correlation coefficients between GC content and Tm are plotted as a function of window sizes. For each chromosome, excluding the segments which contain unknown bases (N's), the correlation coefficient was calculated from all pairs of GC content and average Tm over all nonoverlapping segments of a given window size. Across the chromosomes, the average correlation coefficients and SDs were calculated for each window size. The figure shows the average correlations with SDs (error bars) for window sizes from 10 bp to 1 Mbp for the human chromosomes (red) and the randomized chromosomes (blue).