Comprehensive Annotation of Bidirectional Promoters Identifies Co-Regulation among Breast and Ovarian Cancer Genes
Figure 5
Conserved ETS Factor Binding Sites
(A) Transcription factor-binding sites are shown for the bidirectional promoters of ERBB2, FANCD2, and BRCA2. The vertical arrow points to the binding site preferred by the ETS factor family member ELK1. The legend indicates the identity of all binding sites.
(B) The sequence level view of these ETS factor binding sites are shown as snapshots from the UCSC Human Genome Browser. Horizontal arrows indicate the direction of transcription. Position 0 in (A) corresponds to the transcription start site of the cancer genes in (B). The annotation track labeled “Vertebrate Cons” represents the multiple-sequence alignment and conservation track for the eight-way vertebrate genome comparison at the UCSC Human Genome Browser. The putative ELK1-recognition sequences are boxed. The partner to BRCA2 is not within the range shown.