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Comprehensive Annotation of Bidirectional Promoters Identifies Co-Regulation among Breast and Ovarian Cancer Genes

Figure 4

Co-Regulation of Bidirectional Promoters

(A) The number of bidirectional promoters is graphed for the breast and ovarian cancer genes (solid brown line) and their bidirectional partner genes (solid black line). All graphs have the same axes: (x) the ranking of genes in the expression cluster according to their distance from the target gene and (y) the number of bidirectional promoters identified at this distance.

(B) The correlation coefficient between each breast and ovarian cancer gene and its partner was calculated using the expression data in all 79 tissues. The correlation coefficients are plotted from the largest to smallest values; therefore, the tissue identity may change between plots to accommodate the ordering scheme.

Figure 4

doi: https://doi.org/10.1371/journal.pcbi.0030072.g004