Comprehensive Annotation of Bidirectional Promoters Identifies Co-Regulation among Breast and Ovarian Cancer Genes
Figure 2
Clustering Analysis To Assess Bidirectional Promoters
Clustering methods include microarray expression data (red), GO categories (blue), and psi-blastP alignments (green). The plots show the ratio of bidirectional promoters calculated for the cumulative number of genes found at each promoter distance. The named breast or ovarian cancer gene served as the reference gene for each type of cluster. The computational approach used to count the number of bidirectional promoters within each cluster is described in Methods. GO annotations (blue) were omitted when no data was available.