Cell Size at S Phase Initiation: An Emergent Property of the G1/S Network
Figure 5
Model Predictions of Gene Dosage Effect
The effects on Cdk1-Cln1,2cyt (left panels) and Cdk1-Clb5,6nuc levels (right panels) are compared with wild-type cells. In each panel, wild-type is shown in black, deletion mutants in gray, and overexpressed strains as a dotted line.
(A,B) CLN3 overexpression (OE-CLN3).
(C,D) FAR1 deletion (far1Δ) and overexpression (OE-FAR1).
(E,F) WHI5 deletion (whi5Δ) and overexpression (OE-WHI5).
(G,H) SIC1 deletion (sic1Δ) and overexpression (OE-SIC1).