Cell Size at S Phase Initiation: An Emergent Property of the G1/S Network
Figure 2
Processes Regulating the G1/S Transition in Yeast Cell Cycle
The model comprises transcription of genes coding for cyclins (reactions 1–2), mRNA translation for cyclins, Cdk1, and Ckis (3–9), degradation of mRNA (10–11) and proteins (12–23), reversible or irreversible formation of binary (24–29) and ternary (30–34) protein complexes, Cln3-independent formation of SBF/MBF (35), phosphorylation of protein complexes (36–38), and dissociation of phosphorylated protein complexes (39–41) followed by degradation of the phosphorylated protein. Transport of proteins and protein complexes occurs from cytoplasm to nucleus (42–48) and vice versa (49–53).