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The Importance of Bottlenecks in Protein Networks: Correlation with Gene Essentiality and Expression Dynamics

Figure 5

A Biological Example of a Nonhub–Bottleneck in the Interaction Network

Cak1p is a cyclin-dependent kinase-activating kinase involved in two key signaling-transduction pathways: cell cycle and sporulation.

doi: https://doi.org/10.1371/journal.pcbi.0030059.g005