The Importance of Bottlenecks in Protein Networks: Correlation with Gene Essentiality and Expression Dynamics
Figure 2
Comparison of Essentiality among Various Categories of Proteins within Interaction and Regulatory Networks
(A) Bottlenecks tend to be essential genes in both interaction and regulatory networks. p-Values measure the statistical significance of the different essentialities between bottlenecks and nonbottlenecks.
(B) Essentiality of different categories of proteins. NH-NB, nonhub–nonbottlenecks; H-NB, hub–nonbottlenecks; B-NH, nonhub–bottlenecks; BH, hub–bottlenecks. p-Values measure the statistical significance of the different essentialities between different categories of proteins against nonhub–nonbottlenecks using cumulative binomial distributions (see Methods).