Dynamic Simulations on the Arachidonic Acid Metabolic Network
Figure 6
The Effect of the Mixture and the Dual-Functional COX-2/5-LOX Inhibitors
(A) The effect of MR on the efficacy of the mixture of COX-2/5-LOX inhibitors was simulated.
(B) The effect of DR on the efficacy of the dual functional COX-2/5-LOX inhibitor was simulated.
(C) Comparison of the therapeutic effects of these two kinds of inhibitors. The inhibition intensity on the production of LTs and PGs was calculated to evaluate the efficacy of inhibitors, where I (Mix) is the inhibition intensity of the mixture and I (Dual) is the inhibition intensity of the dual functional inhibitor. ER is the relative activity of COX-2 to 5-LOX, which is 0.02 in the current model. CIt is the total concentration of inhibitors while CEt is the total concentration of COX-2 and 5-LOX. DR is the relative inhibition constant to different enzymes (DR = Ki5-LOX / KiCOX-2), and MR is the mixing ratio of the COX-2 inhibitor and the 5-LOX inhibitor (MR = [COX-2] / [5-LOX]). The efficacy of these two types of inhibitors was compared by the value of difference between I(Dual) and I(Mix).