(A)Symmetric Stem Cell Replication and Cancer
Figure 5
Average Fixation Time of Mutant SC
The average fixation time of mutant SC depends on the relative fitness (A) (red, r = 1.02; blue, r = 1.05), population size (B), and probability of self-renewal (C) (Equation 9). The fixation time for a neutral mutant is always the longest. Although mutants with reduced fitness can reach fixation quickly, this is an improbable event. In all figures, n = 10 (red), n = 50 (green), n = 100 (blue), and n = 400 (black).