(A)Symmetric Stem Cell Replication and Cancer
Figure 2
Representation of the Stochastic Model of Mitotic SC Replication
The model is based on the Moran process, which maintains a constant population size (A) and in which cells are chosen for reproduction proportional to their fitness.
(B) Normal (blue) and mutant (red) SCs may divide asymmetrically with probability p, while they divide symmetrically with probability q to produce two differentiated cells. SCs also can divide symmetrically to produce two daughter SCs with probability 1 − p − q.