UV-Induced Mutagenesis in Escherichia coli SOS Response: A Quantitative Model
Figure 9
SOS Response to Prolonged UV Exposure
(A) LexA (blue) and RecA* (red) levels as a function of time in the presence of a continuous source of UV, which in 300 min (i.e., five cell generations) produces as many lesions as an instantaneous pulse of 20 J/m2.
(B) The presence or absence of mutagenesis in our model in response to a pulse of UV radiation of a given integral intensity (y-axis) and duration (x-axis). Mutagenesis was detected in the colored regions. The criterion for its detection was the Pol V level crossing a specified threshold: 0.1 nM (yellow region), 1 nM (orange region), and 10 nM (brown region).