UV-Induced Mutagenesis in Escherichia coli SOS Response: A Quantitative Model
Figure 8
Saturation of Peak Promoter Activity at High UV Doses
(A) Height of the first (blue curve) and second (red curve) peaks in LexA-regulated promoter activity, averaged more than 200 runs each with a different value of Nf, uniformly distributed between 1 and 3 (other parameters remained fixed as in Figure 4) as a function of the UV dose. Red circles and blue triangles show the corresponding data from Figure 4C of [10]. To facilitate comparison, the height of the red (blue) curve was normalized to match the maximum experimentally observed peak activity.
(B) The peak heights as a function of UV dose for a single run with Nf = 2, with the same normalization as in (A). The saturation of peak heights for increasing UV doses in our model is a consequence of Equation 3.