UV-Induced Mutagenesis in Escherichia coli SOS Response: A Quantitative Model
Figure 5
Activity of a Hypothetical LexA-Regulated Promoter, Parameterized as ∝1/(1+(LexA/100nM))
The blue curve is for default parameters with UV dose 20 J/m2. The position of the second peak coincides with the generation of Pol V and is due to the feedback between Pol V and RecA* levels, mediated by Pol V–assisted bypass of replication forks. The red curve is produced by averaging more than 200 runs of the model, each with a different value for the number of replication forks, Nf, uniformly distributed between 1 and 3 (Nf = 2 for the blue curve).