UV-Induced Mutagenesis in Escherichia coli SOS Response: A Quantitative Model
Figure 4
Mechanism of Pol V to RecA* Feedback
The red line shows the progress in time of a replication fork on DNA with UV-induced lesions. Each yellow bar shows the time span of existence of the RecA filament formed when the fork encounters a lesion. In the absence of Pol V, each RecA filament disassembles before the next one is created. At a later time, when Pol V appears (light blue region), the stall time is substantially reduced, so that a new RecA filament is created before the previous one disassembles, hence the level of RecA* goes up.