A Mathematical Model for Neutrophil Gradient Sensing and Polarization
Figure 14
Predicted Effect of Ras Gap Mutation and Constitutively Active Ras
(A) Ras gap mutation was simulated by decreasing the rate of Ras deactivation (dR) by a factor of 10. The model still polarizes towards the gradient of attractant, but its response to a rotating gradient is slower.
(B) Constitutively active Ras was simulated by setting the Ras deactivation rate (dR) to zero. The model polarizes towards the chemoattractant but cannot track a rotating gradient.