A Mathematical Model for Neutrophil Gradient Sensing and Polarization
Figure 13
Alternative Model of Gradient Sensing and Spontaneous Polarization
(A) Spatial and temporal distribution of ligand-bound receptors, actin, and myosin in response to a 50% gradient of chemoattractant. Gradient direction rotates by 180° from t = 80 − 120s.
(B) Spontaneous polarization in response to a uniform stimulation (bL = 1) with a perturbation of size 0.1 made to the receptor–ligand complex at θ = 0.5. Note that myosin localizes at the site of the perturbation. This behavior is opposite that of the original model.