A Mathematical Model for Neutrophil Gradient Sensing and Polarization
Figure 9
Spontaneous Polarization in Response to Uniform Addition of Chemoattractant
(A) Dynamic response to the addition of chemoattractant (bL = 1 and gL = 0%) with a perturbation of magnitude 0.1 made to the receptor–ligand complex at θ = 0.5.
(B) Sensitivity of spontaneous polarization to perturbation size. Steady-state distribution of PIP3, actin, and myosin in response to uniform addition of chemoattractant (bL = 1 and gL = 0%) with perturbations of increasing size made to the receptor–ligand complex at θ = 0.5.