A Mathematical Model for Neutrophil Gradient Sensing and Polarization
Figure 6
Effect of F-Actin Inhibitor on Signal Polarization
Steady-state distribution of receptor–chemoattractant complexes (black), activated PI3K (red), and RhoA(blue). The simulations were performed using a 100% gradient (bL = 1 and gL = 100%). Weaker gradients yielded a flatter response as the inhibition of actin decreases the sensitivity of the response.