A Mathematical Model for Neutrophil Gradient Sensing and Polarization
Figure 5
Dynamic Range of Gradient Sensing Mechanism
The formula for the chemoattractant concentration on the surface of the cell as a function of the gradient strength (gL) and background concentration (bL) is given in the text.
(A) Steady-state distribution of PIP3, actin, and myosin in response to chemoattractant gradients of increasing steepness with the background concentration of chemoattractant fixed at bL = 1.
(B) Steady-state distribution of PIP3, actin, and myosin for a 10% gradient (gL = 10%) with increasing background concentrations of chemoattractant.