A Mathematical Model for Neutrophil Gradient Sensing and Polarization
Figure 4
Receptor–chemoattractant complexes (black dashed) sharply localize activated PI3K (red) to the front via the PI3K/Ras coincidence circuit. Activated PI3K localizes actin (not shown) which inhibits RhoA (blue) from localizing to the front. The abscissa (θ) is the location on the cell periphery. Chemoattractant concentration on the surface of the cell was specified by the function L(θ) = 1 − 0.25 cos(2πθ).