A Mathematical Model for Neutrophil Gradient Sensing and Polarization
Figure 2
Separation of Front and Back Molecules in Response to a 50% Gradient of Chemoattractant
Spatial and temporal distribution of the front (left) and back (right) signaling molecules. The abscissa is time (dimensionless), the ordinate θ, taking values between zero and one, is the position on the membrane, and the color intensity denotes the concentration. Chemoattractant concentration on the surface of the cell was specified by the function L(θ) = 1 − 0.25 cos(2πθ). The gradient direction rotates by 180° from t = 80 − 120. One dimensionless time unit corresponds roughly to 0.05 s in real time [53].