The (In)dependence of Alternative Splicing and Gene Duplication
Figure 4
The Distribution of Nonconservative Changes along Sequences
The maximal mismatch distance between nonconservative substitutions is much smaller in AS than in GD. The maximal mismatch distance is the number of residues between the two most distant, nonconservative substitutions, normalized by sequence length. Nonconservative mismatches have a negative value in the Blosum62 matrix [65] and were chosen for their stronger impact on protein structure and function. The plot depicts AS data in green, and GD data for families at 80% and 40% seq.id. in light violet and dark red, respectively. We observe that nonconservative substitutions in AS are much more localized than those in GD.