Repressor Dimerization in the Zebrafish Somitogenesis Clock
Figure 4
Stochastic Simulations of a Chain of Oscillators Corresponding to the Model Sketched in Figure 1, with Normal Coupling through Delta-Notch Signaling (A–C) and with Disrupted Coupling (D–F)
When coupling was absent, some cells were noticeably out of synchrony with their neighbors (arrowheads), and local synchrony was not as strong. The transcription rate of her1 and her7 was increased in (D–F) to make up for the loss of Notch signaling.