Repressor Dimerization in the Zebrafish Somitogenesis Clock
Figure 3
Deterministic Simulations of a Chain of Oscillators Corresponding to the Model Sketched in Figure 1 (See Table 1 for Values of Parameters)
Waves of expression spread from posterior to anterior PSM (A–C), as observed experimentally. To test the effect of oscillator-coupling through DeltaC-Notch signaling, a perturbation was induced by delaying a number of oscillators in the chain by 5 min (D). After 1.3 h, the resulting perturbations in the spatial pattern were reduced (E); note that cells corresponding to indexes smaller than 13 on the x-axis should show no perturbation, because they were added to the chain after the initial perturbation.