Synonymous Substitution Rates Predict HIV Disease Progression as a Result of Underlying Replication Dynamics
Figure 3
Scatter Plots of Mean Synonymous (A) and Nonsynonymous (B) Substitution Rates on Backbone Branches as a Function of Progression Time, CD4+ T Cell Count Slope, and Log Viral Load Slope
Rates as a function of progression time and the slope of the CD4+ T cell count are shown in pink, while rates as a function of the log VL slope are shown in cyan. The progression time for patient 11 was set at the last sampling time (144 months), although the CD4+ count had not dropped below 200 cells/μl at that time [14,17]. The slope of the CD4+ T cell count and log VL were calculated based on linear regression of these parameters as a function of time. The error bars represent the standard errors of the estimates.