Dose Response Relationship in Anti-Stress Gene Regulatory Networks
Figure 6
Effect of Saturation of Enzyme G Activity by Controlled Variable Y on Systems-Level Gains and Dose Response Curves
(A) In the absence of feedback control, saturation of G by Y causes a sublinear catastrophic increase in Y in response to S (dotted line); in the presence of feedback control, the Y versus S dose response curve (solid line) grows in a much suppressed, superlinear fashion; the corresponding systems-level gain is low and varies only slightly as suggested by Equation 12.
(B) The enzyme G versus S dose response curve (solid line) grows in a nearly linear fashion, as the systems-level gain increases to approach unity according to Equation 14.